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Skin Booster

Skin Boosters: Ingredients and Differences by Type?

Skin Booster Comparison Based on Hyaluronic Acid, PN, PDRN, Exosomes, and PDLLA

Chief Director Seo Min-hoEPISODE CLINICcheck 21great 1

"I want to use a skin booster, but I don't know what's what."


This is something I hear very often in the counseling room.

Aqua Injection, Rejuran, Salmon Injection, Exosome, Juvelux Skin..

All of these are called skin boosters, but the ingredients they contain are all different.


Today, I'm using a skin booster. Ingredient StandardsI will organize it by dividing it into.

What goes in and what role those ingredients play in the skin

If you know just this, you won't get confused no matter how many types there are.


image.pngVarious skin boosters



0. To start with the conclusion


Skin boosters are What to put inIt is divided into.

The criteria I use when counseling are five categories.


Five Types of Skin Boosters by Ingredient

Even if they are the same 'skin booster,' they do different things depending on the ingredients used.

Hyaluronic acid

HA

Hydro-glow Injection, Belotero Revive - Draws moisture from the dermis

PN

polynucleotide

Rejuran - Acts as a support structure within the dermis to create an environment for skin recovery.

PDRN

Polydeoxyribo
nucleotide

Salmon Injection - Lowers inflammatory signals and accelerates the recovery of damaged tissue

Exozem

exosome

ASCE+ - Transmits signals exchanged between cells (topical application)

PDLLA

Polydielactic acid

Juveluxkin - Promotes the growth of your collagen and elastin around the particles


Mix these ingredients here and put them in all at once. Skin texture therapyThere is.

Let's look at them one by one.


1. Hyaluronic Acid - Replenishes moisture


Hyaluronic acid is a component naturally found in the dermis of our skin.

There are spots throughout the chain that hold water, so it embraces water hundreds of times its own weight.

As we age, the amount decreases, and a hyaluronic acid skin booster is designed to replenish that lost amount with the same ingredient.


Here, it branches out one more way. BridgeIt is whether or not you did it.


Non-cross-linked hyaluronic acidWater-glow injectionThe chains are separate, so it is thin and spreads well.Lasts 1 to 2 monthsCPM cross-linked hyaluronic acidBelotero ReviveA net with a mix of dense and loose sectionsLasts for 3 to 6 months (based on the first 3 sessions)

Even with the same hyaluronic acid, the time it stays in the body varies depending on whether or not it is cross-linked.


Water-glow injectionis not the official product name.

It is a general term for a procedure in which small amounts of non-crosslinked hyaluronic acid are injected widely into the shallow dermis.

It is thin and spreads well, but it breaks down quickly, so it lasts for about 1 to 2 months.


Belotero ReviveThis is an official product of Merz, Germany.

CPM cross-linked hyaluronic acid 20 mg/mL contains 17.5 mg/mL of glycerol.

When hyaluronic acid attracts water, glycerol holds onto it in the stratum corneum to prevent it from escaping.

So, not only does hydration increase, but the skin barrier also improves.


Two types of hyaluronic acid skin boosters

Water-glow injection

moisture

Non-cross-linked hyaluronic acid

We directly inject moisture-retaining ingredients into the dermis.

1g holds up to nearly 6L of water.

33G needle, the size of a business card per 1cc

Lasts 1 to 2 months

Belotero Revive

Moisture + Barrier

CPM Cross-linked Hyaluronic Acid 20mg/mL + Glycerol 17.5mg/mL

Hyaluronic acid attracts, and glycerol holds onto.

Shallow and dense with 34G 2mm ultra-fine needles

At 3-month intervals, the first 3 times at 1-month intervals.

Lasting 3 to 6 months


(The difference in ingredients between Aqua Injection and Revive is explained in detail in the previous post, "What Exactly Is the Difference Between Aqua Injection and Revive?")


2. PN - Creates an environment for the skin to recover.


PN (polynucleotide)It is a DNA fragment obtained from salmon.

It is known as a material that causes less foreign body sensation or rejection because its base composition is 97% similar to human DNA.


PN is a transparent gel with constant viscosity.

If you go inside the dermis Scaffold It creates an environment where the skin heals itself while performing its role.

It is not a procedure to fill in sunken areas and change the shape, but rather a procedure that improves the skin's foundation.


The flagship product RejuranAnd there are four types.


PN Skin Booster, Rejuran, and four types

The main ingredient is PN for all of them. The needles, viscosity, and included ingredients differ.

Rejuran

Basic form

PN 40mg / 2mL

Skin texture and fine lines on the entire face

33G 4mm needle

Pain 5/5, anesthesia required

Rejuran i

eye area

PN 20mg / 1mL

For eye area and under-eyes only (eye skin thickness approx. 0.5mm)

Shallowly on thin skin with a 34G needle

Rejuran HB

moisturizing

PN 10mg + HA 10mg + Lidocaine 2.8mg / 1mL

A product that adds moisture to recovery

When inner tightness and dryness occur together

Pain 3/5

Rejuran S

scar

PN 20mg / 1mL, increases viscosity

Indentations, curves

From the deep layer with a 30G 8mm long needle

All four products At least 3 times at 1-month intervalsThe duration is 1 to 2 months (varies from person to person).


Even within the same PN, properties vary depending on the length of the DNA fragment.

Rejuran is manufactured using the manufacturer's (Pharmaresearch) patented DOT technology, adjusting the molecular weight range to suit the specific purpose of each product.


(The differences between the four types of Rejuran are summarized in the article "Types of Rejuran, What Are the Differences?")


3. PDRN - Reduces inflammation and accelerates recovery


Salmon injectionIt is a procedure called...

It is a nickname given because the raw materials are obtained from salmon, and the ingredients are PDRNno see.


Isn't Rejuran also salmon?


That is correct. Both are salmon-derived DNA.

The difference is Length of DNA chainno see.


PNRejuranLong DNA chains, viscous gelIt remains as a scaffold within the dermis.Fine lines, skin texture, elasticityPDRNSalmon injectionShort DNA fragments, low viscoelasticityIt does not stay like gel but breaks down and emits a signal.Redness, sensitivity, post-procedure recovery

Both are salmon-derived DNA, but they do different things depending on the chain length.


PN has long chains, so it remains in the dermis as a viscous gel, and

PDRN is a short fragment with low viscoelasticity, so it does not remain like a gel but breaks down within the tissue and emits signals.


As PDRN decomposes Adenosine A2A receptor Activate the path.

It lowers inflammatory signals and raises signals involved in tissue regeneration and angiogenesis.

Degraded nucleotides are recycled and reused as materials to repair damaged cells.


PDRN Skin Booster, Salmon Injection

Salmon injection

recovery

PDRN, a DNA fragment extracted from the germ cells of salmonid fish and purified to a high degree.

It lowers inflammatory signals and raises recovery signals via the adenosine A2A receptor pathway.

Degraded nucleotides are recycled and become materials for repairing damaged cells.

Irritated and sensitive skin, recovery after procedure

Treatment interval: 2 weeks to 1 month


So, I share it like this.

Overall skin condition, such as fine lines, elasticity, and skin texture PN,

Irritated and sensitive skin, redness, and post-procedure recovery PDRN.


4. Exosomes - Transmit signals exchanged between cells


There is a reason why your skin is not recovering as quickly as it used to.

As the signals exchanged between skin cells slow down, recovery is slower even with the same stimulation, and redness persists for a long time.


ExozemIt is a very small endoplasmic reticulum that the cell produces and releases on its own.

It contains proteins, miRNA, and lipids, and these contents are transferred to adjacent cells all at once.

It is different from the method of adding only one growth factor.


There is one thing I absolutely must mention here.

The one we use ASCE+ SRLVis not an injection Topical productsno see.

Since it is a product distributed as a topical cosmetic, it uses the application method + exosome pumping tip or MTS, which is within the permitted scope.

Even good ingredients do not reach the cells well by simply applying them, so we first create tiny channels before applying them.


Exosomes, ASCE+ SRLV

It is a topical product, not an injection.

ASCE+ SRLV

signal

Adipose stem cell-derived exosome freeze-dried powder + activation solution

Proteins, miRNAs, and lipids inside exosomes are delivered to adjacent cells all at once.

The powder contains 5 types of growth factors, 19 types of amino acids, and 6 types of peptides, while the solution contains hyaluronic acid and growth factors.

A product containing only exosomes using ExoSCRT purification technology

Treatment interval: 1 month

Step 1

Creating a passageway

Create micro-channels in the stratum corneum using an MTS or Potenza pump tip.

This is because the skin can barely allow large molecules larger than 500 Da to pass through.

Step 2

embrocation

Dissolve the powder in the solution and apply it.

It is delivered to the epidermis and upper dermis through open channels.

Step 3

Signal transmission

Fibroblasts receive signals and produce collagen and elastin.

It regulates inflammation signals to reduce redness.


For exosome products, you must first look at the purification technology.

Since they are present in very low concentrations within the culture medium, the quality varies significantly depending on the process of filtering out impurities and leaving only exosomes.


5. PDLLA - Regenerates collagen


The reason skin texture becomes rough and fine lines increase is not solely due to a lack of moisture.

The dermis that supported the skin from the inside collagenThis is because the support decreases as it shrinks.


Jubelux SkinIt injects PDLLA and hyaluronic acid into the dermis,

It is a tissue repair material that stimulates the growth of collagen and elastin around the particles.

It works differently from hyaluronic acid skin boosters that replenish moisture.


PDLLA Skin Booster, Jubelux Skin

It doesn't just replenish moisture, but regenerates collagen.

Jubelux Skin

collagen

PDLLA (Polydielactic Acid) + Hyaluronic Acid

Non-crystalline, amorphous, hollow porous network particles

It lowers enzymes (MMPs) that break down collagen, and collagen and elastin grow around the particles.

There is no change the day after the procedure, but elasticity improves over time.

3 times at 1-month intervals, duration 12–16 months, pain 4/5


So, it does not change the day after the procedure.

Instead, elasticity gradually increases over time, and the duration is the longest at 12 to 16 months.


(The differences between PDLLA and PLLA, CaHA, and PCL are explained in the post "The Golden Age of Collagen Boosters.")


6. Compare at a Glance


ingredientWorkcontinueinterval
Hyaluronic acidWater-glow injectionAttracting moisture1~2 months1~2 months
HA + GlycerolRevivePulling and holding3~6 months3 months
The first 3 sessions are for 1 month
PNRejuranRecovery environment, fine lines, skin texture1~2 months1 month, 3 times or more
PDRNSalmon injectionInflammation control, recovery-2 weeks to 1 month
ExozemASCE+ (applied)Cell signal transduction-1 month
PDLLAJubelux SkinCollagen production12~16 months1 month, 3 times


If you look at the table, 'how far it goes' varies quite a bit depending on the ingredient.

It takes 1 to 2 months for Aqua Injection and Rejuran, 3 to 6 months for Revive, and over 1 year for Juveluxkin.

Just because something lasts a long time doesn't automatically mean it's good; since each performs different functions, choosing the right one for your purpose is the priority.


7. So, what works for my skin?


Skin boosters that come to mind first for each concern

If your main concern is inner tightness and dryness after washing your face

Water-glow injection

If you experience prolonged inner dryness and frequent redness even after applying moisturizer

Revive

If you are concerned about fine lines, skin texture, or thinning skin

Rejuran

If you have sensitive skin, redness, or slow recovery after the procedure

Salmon injection

If you want to signal skin recovery without injections

Exozem

If you want a change that lasts a long time and loses momentum

Jubelux Skin

If you are concerned about moisture, regeneration, and sebum all at once

Skin texture therapy


It is rare to have only one concern.

It is often dry, has a rough texture, excessive sebum, and is prone to enlarged pores.

So, I mix skin boosters with different ingredients and put them in at once. Skin texture therapyI made.


Mix and All at Once, Skin Texture Therapy

PN + Hyaluronic Acid + Botulinum Toxin + EPISODE Pain Relief Formula

PN

The overall regenerative environment of the skin

Hyaluronic acid

Draws moisture from the dermis to reduce dryness

Botulinum toxin

Insert shallowly to remove sebum and pores

Pain relief combination

By combining lidocaine and the like, it makes it less painful from the moment of injection.

The product is opened and mixed right in front of you immediately before the procedure, and injected using an X-Injector. Pain is 2/5, lasting 3–6 months.


PN, hyaluronic acid, and toxin are separate products that have each received approval, so they are not sold pre-mixed.

Therefore, immediately before the procedure, we open the product in front of the patient and mix it according to the specified ratio.

What and how much was administered is recorded exactly as it is in the procedure report.


8. In conclusion..

To summarize, it is as follows.


  1. Hyaluronic acidIt replenishes moisture (water glow injection), and when glycerol is added, it retains it (revive).

  2. PN(Rejuran) creates an environment for recovery, and PDRN(Salmon injection) reduces inflammation and accelerates recovery.

  3. ExozemIt is a topical product that transmits cell signals, and PDLLA(Juveluxkin) regenerates collagen.


For skin boosters, you should look at the ingredient list first, rather than the name.

The product you choose depends on whether your skin needs moisture, recovery, or collagen right now.


This article Which skin booster should I get? I hope this helps with your question.

This has been Seo Min-ho. Thank you for reading.