EPISODE CLINIC
Ko

[Botox]

Differences Between Botox Products: What Are the Differences?

Comparison of Hytox, Coretox, Xeomin, Dysport, and Botox

Chief Director Seo Min-hoEPISODE CLINICcheck 120great 1

It's the same Botox (botulinum toxin), so what on earth is the difference?


In the previous post, I explained how Botox works and breaks down inside the body.

And finally, I mentioned that even within the same Botox, the ingredients, duration, and price vary from product to product.

Today, the five products used in the EPISODE, Hytox, Coretox, Xeomin, Dysport, Botox (Allergan)I will compare them one by one.


image.pngVarious Botulinum Toxin Friends


In this article, to avoid confusing names, I will refer to the original product made by Allergan as 'Botox (Allergan).'


1. All five products are the same Type A toxin.

All five products Botulinum Toxin Type Ano see.

The principle of inhibiting muscle contraction by severing SNAP-25 at the nerve ending is also the same.

The difference between products is Complex protein, unit, price There are three.


Five Products at a Glance
productmanufacturing companyFirst permit
Botox (Allergan)importAllergan (USA)1989 US FDA
DisportimportIbsen (France)US FDA in 2009
XeominimportMerz (Germany)US FDA in 2010
CoretoxdomesticMeditox (Korea)2016 Ministry of Food and Drug Safety
HitoxdomesticKorea BMI (Korea)2024 Ministry of Food and Drug Safety
Based on the year of approval by the U.S. FDA for imported products and the Ministry of Food and Drug Safety for domestic products.


Botox (Allergan) is the original product that was the first to be approved, and all the remaining products are also officially approved.


2. Whether or not complex proteins are present

The neurotoxin that actually produces the effect in botulinum toxin is 150kDa It is a protein of that size.

When bacteria produce toxins, other proteins attach to this neurotoxin and are released together, and this complex proteinIt is called.

Botox (Allergan) includes even this complex protein, the drug 900kDa It is the size.

Xeomin and Coretox remove complex proteins and 150kDa This is a product that leaves only neurotoxins.


Difference between the presence and absence of complex proteins (conceptual diagram)
Includes complex proteins
Approximately 900kDa
Botox (Allergan), Dysport, Hytox
Removal of complex proteins
150kDa
Xeomin, Coretox
Neurotoxin (the part that actually produces the effect)complex protein
900kDa is the standard for Botox (Allergan), and there are slight differences for other products.


Complex proteins are not directly involved in inhibiting muscle contraction.

However, because the body may recognize it as a foreign substance, Xeomin and Coretox removed complex proteins to lower the likelihood of antibody formation.


If antibodies are produced, the effect weakens even with the same dose, and this toleranceIt is called.

While tolerance is not common, it is known that the likelihood increases with higher doses administered at once and shorter intervals.

So, if you are concerned about developing resistance after repeatedly receiving high-volume treatments such as square jaw or trapezius muscle reduction, you may consider Coretox or Xeomin.


3. There is a difference in units.

Botox dosage is indicated in 'units (U)'.

However, since the method of measuring effectiveness varies by manufacturer, even products with the same 100 units do not have the same quantity.

especially DisportThe unit system is different, so you should not compare it directly with other products based solely on the numbers.


Therefore, when changing products, you should not just match the numbers, but also re-select the capacity that meets the product's standards.

Generally, you can consider 500 units of Dysport to produce a similar effect to 200 units of other toxins.


Since it can be confusing, Disport usually reduces the units to a different ratio of 1:2.5 to standardize the terminology.

And with any product, before the procedure Check the product and capacity right in front of your eyesDoing so is the basic.


image.pngChecking the Botox product and dosage right before your eyes before the procedure


4. There is a price difference.

The biggest difference you will feel is, of course, the price.


Price comparison by product
Wrinkle Botox
Based on 3 parts
Hitox
50,000 won range
Coretox
Around 100,000 won
Xeomin
100,000 won range
Disport
100,000 won range
Botox (Allergan)
400,000 won range
Square jaw Botox
Based on 100U
Hitox
40,000 won range
Coretox
Early 100,000 won range
Xeomin
Late 100,000 won range
Disport
Late 100,000 won range
Botox (Allergan)
400,000 won range
It is an average price range.


For the same square jaw 100U, Hitox is in the 40,000 won range, while Botox (Allergan) is in the 400,000 won range. Nearly ten times There is a difference.

However, that does not mean the effect is ten times stronger. Since the principle is the same, the results vary more significantly depending on the design and capacity than on the product itself.


5. So, which product should I choose?

The criteria I provide during consultations are as follows.


I recommend this to people like this.
productsuggestion
HitoxIt is the most affordable, so for those getting Botox for the first time
CoretoxDomestic product with complex proteins removed, for those concerned about resistance from repeated injections
XeominImported product with complex proteins removed, for those concerned about resistance from repeated injections
DisportImported product that received feedback that it 'lasts longer' even with the same unit
Botox (Allergan)For those who want original Botox, genuine product


However, what needs to be decided before selecting a product is still Design and capacityno see.

Because even good fabric won't make a good garment if the size doesn't fit.


6. In conclusion..

To summarize, it is as follows.


  1. All five products Botulinum Toxin Type AAnd, muscle contractionsecond controlThe principle is the same.

  2. Xeomin and Coretox have complex proteins removed 150kDa As a product, it can be considered when there is concern about resistance due to repeated procedures.

  3. The result of the procedure is designclass volumeIt varies more significantly depending on.