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[Botox]

The reason why Botox (Botulinum Toxin) treatment is most recommended

The most basic cosmetic procedure

Chief Director Seo Min-hoEPISODE CLINICcheck 71great 1

I receive this question very often during consultations.

Director, what should I get first?


I almost always BotoxI recommend starting from here.

This is because it is the cheapest, most effective, and oldest procedure.

Today, I will explain why that is the case, as well as how Botox works and breaks down inside the body.


The official name is botulinum toxin, and 'Botox' is originally a product name of a specific company; however, since 'Botox' is a commonly used generic term, I will refer to it as such in this text for the sake of readability.


image.pngAllergan's original product, Botox

1. How did Botox start?


Botox is originally causative agent of food poisoningIt was.

In the 1820s, a German doctor recorded patients whose muscles became paralyzed after eating spoiled sausages and predicted that this 'sausage poison' could one day be used for treatment.

And about 150 years later, an American ophthalmologist cross-eye It was first used for treatment. It was intended to weaken the muscles that pull the eye in the wrong direction.


The beauty effect by chance It was discovered.

patients being treated for eyelid spasms Smoothing out wrinkles between the eyebrowsAn ophthalmologist noticed this and, together with her husband, a Dermatology , published it in 1992.

After that, it became the Botox we know today after receiving official approval for frown lines in 2002.


Until Botox became a cosmetic procedure

1820s

German doctor Kerner records spoiled sausage poisoning

The causative substance is called 'sausage poison,' and it is predicted that it could be used for treatment someday.

1895

Discovery of causative bacteria

Belgian scientist Van Ermengem discovered botulinum toxin.

1970s

American ophthalmologist Alan Scott, used for strabismus treatment

First used to weaken the muscles that turn the eyes

1989

First US FDA approval

As a treatment for strabismus and eyelid spasms

1990s

Discovering that the wrinkles between the eyebrows of a patient with eyelid spasms are smoothed out

Released by the Carothers couple in 1992, the beginning of cosmetic use

2002

US FDA approval of frown lines

Subsequently, its use expanded to include square jaw, trapezius muscles, hyperhidrosis, etc.


In other words, Botox is A procedure proven worldwide for over 30 yearsno see.


2. Why would I recommend it first?


The reason is 4 typesI can explain it briefly and strongly.


The reason I recommend Botox first

1

One of the most affordable procedures

It is one of the least expensive cosmetic procedures.

price

2

The effect is certain

Since it works on the principle of inhibiting muscle contraction, the results are predictable.

effect

3

The oldest procedure

Used worldwide for decades since approval in 1989

safety

4

It'll be over in 10 minutes.

Injection only, no anesthesia; immediate return to daily life.

hour


Even if newly released equipment or injections look good at the time, they sometimes go out of fashion a few years later.

Botox is a procedure that has already been used for decades and has been fully evaluated.

It is affordable, the results are predictable, and the procedure takes only 10 minutes.

That is why I always start by explaining Botox to those who are new to cosmetic procedures.


3. How does Botox work?


For a muscle to move, nerves must transmit a signal to the muscle to 'move'.

This signal comes from the nerve ending AcetylcholineA substance called [name] delivers.


Acetylcholine is stored in a small sac inside the nerve ending, and is released when the sac attaches to the membrane of the nerve ending.

At this time, there is a protein that attaches the sac to the membrane, and one of them is SNAP-25no see.


Botox enters the nerve endings and this Cut the SNAP-25.

Since the sac cannot adhere to the membrane, acetylcholine cannot be released, and the muscle does not receive the signal, so contraction is inhibited.


Usuallymuscle fibers12nerve endingsSNAP-2534576The muscles contract.
If you get Botoxmuscle fibers12nerve endingsBBotoxBSNAP-2534576Muscle contraction is inhibited.
1Axon (covered in myelin)
2nodule
3Mitochondria
4Acetylcholine sac
5Active zone
6synaptic cleft
7Folded membrane, receptor

Botox cleaves SNAP-25 (a protein that attaches acetylcholine sacs to the membrane) inside the nerve ending.


Botox acts between nerves and muscles.

Usually

The brain sends a signal to 'move'

▼

Acetylcholine is released from the nerve endings

▼

The muscle receives and contracts.

If you get Botox

Botox is injected into the nerve endings.

▼

Cleave the protein (SNAP-25) required for acetylcholine release

▼

Muscle contraction is inhibited because the signal is not transmitted

Nerves and muscles are not damaged, and only signal transmission between them is temporarily blocked.


In this process, nerves and muscles It will not be damaged.

Because it only temporarily blocks signal transmission between the two, the muscle moves normally once transmission is restored.


4. A duration of 3 to 6 months is actually better.


The duration of Botox is usually 3~6 monthsno see.

Many people ask, "Then don't you have to keep getting it?" with disappointment, but I actually think this is Botox's meritI think so.


The muscles in our body It continues to change as you age.

The Botox design needed in your 20s cannot be the same in your 40s. If the effect were permanent, your face would change, but the drug's effects would remain, making it look unnatural.


And Botox is an injection administered by a person.

In very rare cases, it can be injected into unwanted muscles, and if it is a permanent procedure, it will be irreversible.

However, over time, Botox It will definitely return to its original state. This is the biggest reason why it has been used safely for decades.


What if the effect were permanent?

If it is permanent

Even as muscles change with age, it remains the same as the original design

It cannot be reversed even if it enters unwanted muscles

Even if trends and tastes change, it cannot be reversed

In 3 to 6 months

Redesigned to match changes in the face at any given time

Even if it feels awkward now, it will return to normal over time.

Adjusting the dosage and area to fit.


5. Why does the effect return?


The process of the effect returning is as follows.


The effects of Botox begin to appear 2 to 3 days after injection and reach their peak around 2 weeks.

About a month later, at the end of the nerve New branchIt sprouts and forms a temporary connection (synapse) with the muscle. From this point, the muscle begins to move little by little.


And after 2 to 3 months, the original nerve ends Create a new SNAP-25 Restores the original passage.

When the original passageway opens, the temporarily sprouted branches disappear, and it returns completely to its original state.


1. Effect lasts (2 weeks to 1 month)
muscle fibers12nerve endingsBBotoxBSNAP-2534576
Muscle contraction is inhibited.
2. About 4 weeks, new branches sprouted
muscle fibers12New branchnerve endingsBSNAP-2534576
Moving little by little via a temporary connection
3. 2–3 months, restoration of original passageway
muscle fibers12The new branchdisappearancenerve endingsSNAP-2534576
It moves back to its original state.
1Axon (covered in myelin)
2nodule
3Mitochondria
4Acetylcholine sac
5Active zone
6synaptic cleft
7Folded membrane, receptor

The receptors in the muscles remain intact, and the effects return as the nerve endings recover.


The process of the effect returning

2~3 days

The effects began to appear

Muscle strength decreases as the severed SNAP-25 stretches

around 2 weeks

Maximum effect

From about 4 weeks

New branches sprout from the ends of nerves

It creates temporary connections (synapses) and the muscles begin to move little by little.

2~3 months

The original nerve endings are restored

The original passage was restored by creating a new SNAP-25.

3~6 months

The temporary branches disappear and return to the original state.

The muscle receptors remained the same from the beginning.

Therefore, Botox is a procedure where the results definitely return to normal over time.


For reference, muscle receptors are not affected by Botox.

The effect returns nerve endingsThis is because it is recovering!!


6. How is Botox broken down?


One of the frequently asked questions is, "Doesn't Botox remain in the body?"


Botox is proteinno see.

The injected Botox enters the nerve endings near the injection site. It does not travel throughout the body via the bloodstream.

Inside the nerve ending, the cell originally possesses Protein degradation processIt is gradually broken down through the process and eventually becomes amino acids, which are recycled within the body.


The severable SNAP-25 is also replaced with a new protein.

When Botox is broken down and SNAP-25 is refilled, the signaling pathway opens, and the effect of Botox ends.


How does Botox disappear?

The injected Botox enters the nearby nerve endings.

It does not circulate throughout the body via the blood.

▼

It is gradually broken down inside the nerve end.

Since it is protein, it eventually becomes amino acids and is recycled.

▼

The cleaved SNAP-25 was also replaced with a new protein.

The effect ends when the signal channel reopens.

Botox is a protein that is sensitive to heat. This is why you are advised to avoid saunas and hot compresses immediately after the procedure.


The breakdown rate varies slightly depending on the type of Botox (Type A), so the duration of effect also differs.

And since it is protein It is sensitive to heat. This is why we advise you to avoid saunas or hot compresses immediately after the procedure.


7. In conclusion..


To summarize, it is as follows.


Botox in One Page

1

The cheapest, most effective, and oldest procedure

Approved in 1989, the foundation of cosmetic procedures used for over 35 years

2

Temporarily blocking only signal transmission between nerves and muscles

Neither nerves nor muscles are damaged

3

Lasting 3 to 6 months is actually an advantage.

Redesigned to match facial changes, returns to original even if it looks awkward.

4

The reason for the return is the recovery of the nerve endings

New branches sprouted, and the original passageway was restored.

5

Since it is protein, it breaks down and disappears inside the body.

Avoid sauna immediately after the procedure as it is sensitive to heat.


Botox is a cosmetic procedure The most basicno see.

It is cheap, effective, long-lasting, and above all, it will definitely return.

If you are considering a procedure for the first time, I recommend starting with Botox.


However, even with the same Botox For each product The ingredients, duration, and price differ.

In the next post, we will write By productI will guide you through them one by one.

This has been Seo Min-ho. Thank you for reading.